While pizza presents a mixed bag when it comes to delivering nutrition (especially because there are so many ways to eat healthy pizza and lose weight), you definitely don’t want to overindulge in this treat. Pizza can present some decent nutrition when served up in the right form, but like most other foods, you can easily overdo this junk food. If you enjoy pizza but eat too much of it, you can face some ugly side effects of pizza that could lead to serious damage to your health.

When you want to take it easy on your body, avoid that extra slice of pizza to dodge these 6 terrible ugly side effects of eating pizza. And for even more healthy tips, be sure to check out this list of 7 Healthiest Foods to Eat Right Now.

Weight gain

Because pizza is high in carbs and fat and doesn’t include a ton of fiber (unless it’s made with a whole-grain crust, and loaded with vegetables), you’ll likely still feel hungry after eating a slice. A recent study found that our bodies are surprisingly good at overindulging in food—especially with something as tasty as pizza. Without anything on the pizza to keep you feeling full—like filling up on high-fiber foods and lean proteins—you’ll likely overindulge because your body won’t recognize that it’s full, making pizza a food that can seriously pack on the pounds. Plus, after remembering how many empty calories end up in a slice of pizza, anyone can resist the urge to pick up a second slice.

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Increased risk of heart disease

According to Domino’s, you can easily top off any size of pizza with enough saturated fat to do some real damage on your arteries in the form of sausage, pepperoni, extra cheese, and more. This comes as unwelcome news to anyone with a family history of heart failure, or anyone who simply wants to avoid unnecessary plaque buildup around their arteries. According to the American Heart Association, you can find a ton of saturated fats in red meats and cheese. So if you love these toppings, don’t go heavy on the meats (maybe just choose one!) and add in a few vegetables as a topping instead, so you can steer clear of ruining your heart health.